ABSTRACT
Nowadays, it is necessary a better airborne transmission understanding of respiratory diseases in shared indoor and semi-indoor environments with natural ventilation in order to adopt effective people's health protection measures. The aim of this work is to evaluate the relative exposure to SARS-CoV 2 in a set of virtual scenarios representing enclosed and semi-enclosed terraces under different outdoor meteorological conditions. For this purpose, indoor CO2 concentration is used as a proxy for the risk assessment. Airflow and people exhaled CO2 in different scenarios are simulated through Computational Fluid Dynamics (CFD) modelling with Unsteady Reynolds-Averaged Navier-Stokes (URANS) approach. Both spatial average concentrations and local concentrations are analyzed. In general, spatial average concentrations decrease as ventilation increases, however, depending on the people arrangement inside the terrace, spatial average concentrations and local concentrations can be very different. Therefore, for assessing the relative exposure to SARS-CoV 2 it is necessary to consider the indoor flow patterns between infectors and susceptibles. This research provides detailed information about CO2 dispersion in enclosed/semi-enclosed scenarios, which can be very useful for reducing the transmission risk through better natural ventilation designs and improving the classic risk models since it allows to check their hypotheses in real-world scenarios. Although CFD ventilation studies in indoor/semi-indoor environments have been already addressed in the literature, this research is focused on restaurant terraces, scenarios scarcely investigated. Likewise, one of the novelties of this study is to take into account the outdoor meteorological conditions to appropriately simulate natural ventilation.
ABSTRACT
This paper aims to provide scientific support for decision-making in the field of improving air quality by evaluating pollution reduction measures included in the current Spanish policy framework of the 1st National Air Pollution Control Programme (NAPCP). First, the health impacts of air quality are estimated by using the concentrations estimated by multiscale air quality modeling and the recommended concentration–response functions (CRF), specifically as a result of exposure to particulate matter (PM), nitrogen dioxide (NO2), and ozone (O3). Second, the associated external costs are calculated by monetization techniques. Two scenarios are analyzed: a package including existing measures (WM2030) and a package with additional measures (WAM2030). Compared with the baseline scenario, an improvement was found in the health effects of NO2, PM10, and PM2.5, while for O3 there was a slight worsening, mainly due to the increase in the O3 metric used (SOMO35), which increases over some urban areas. Despite this, the monetary valuation of the total effects on health as a whole shows external benefits due to the adoption of measures (WM2030), compared with the reference scenario (no measures) of more than € 17.5 billion and, when considering the additional measures (WAM2030), benefits of about € 58.1 billion.
ABSTRACT
The aim of this study is to analyze the concentrations of cytokines in tear of hospitalized COVID-19 patients compared to healthy controls. Tear samples were obtained from 41 healthy controls and 62 COVID-19 patients. Twenty-seven cytokines were assessed: interleukin (IL)-1b, IL-1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL9, IL-10, IL-12, IL-13, IL-15, IL-17, eotaxin, fibroblast growth factor basic, granulocyte colony-stimulating factor (G-CSF), granulocyte-monocyte colony-stimulating factor (GM-CSF), interferon (IFN)-γ, interferon gamma-induced protein, monocyte chemo-attractant protein-1, macrophage inflammatory protein (MIP)-1a, MIP-1b, platelet-derived growth factor (PDGF), regulated on activation normal T cell expressed and secreted, tumor necrosis factor-α and vascular endothelial growth factor (VEGF).In tear samples of COVID-19 patients, an increase in IL-9, IL-15, G-CSF, GM-CSF, IFN-γ, PDGF and VEGF was observed, along with a decrease in eotaxin compared to the control group (p < 0.05). A poor correlation between IL-6 levels in tear and blood was found. IL-1RA and GM-CSF were significantly lower in severe patients and those who needed treatment targeting the immune system (p < 0.05). Tear cytokine levels corroborate the inflammatory nature of SARS-CoV-2.